Developmental toxicity of nonylphenol in zebrafish (Danio rerio) embryos

Present study reports the response of zebrafish embryos exposed in vivo to graded concentrations of Nonylphenol (NP), ranging from high lethal levels to lower, more environmentally relevant levels. Embryos treated with NP showing developmental abnormalities and morphological alterations in a dose-dependent pattern. Results suggest that early exposure to NP can cause direct and delayed mortalities or even non-lethal malformations at doses more than 0.3 µM, while EC50 was shown to be 1 µM after 6 days of exposure.