2015•SteroidsRequires access

Investigation on bile acid receptor regulators. Discovery of cholanoic acid derivatives with dual G-protein coupled bile acid receptor 1 (GPBAR1) antagonistic and farnesoid X receptor (FXR) modulatory activity

Valentina Sepe, Barbara Renga, Carmen Festa, Claudia Finamore, Dario Masullo, Adriana Carino, Sabrina Cipriani, Eleonora Distrutti, Stefano Fiorucci, Angela Zampella

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Key concepts: Farnesoid X receptor, G protein-coupled bile acid receptor, Bile acid, Liver receptor homolog-1, Nuclear receptor, Receptor, Small heterodimer partner, Biology