CONTINUOUS CELL SEPARATION BY CHIP-BASED TRtKVELING-WAVE DIELECTROPHORESIS AND LAMINAR FLOW

A novel method for continuous cell separation is developed by integrating traveling-wave dielectrophoresis (twDEP) and laminar flow on a single biochip-based device. The separation of heterogeneous population of different cells is based on the difference between their dielectrophoretic characteristics and densities. Our preliminary experiment proved this theory by demonstrating the separation of red blood cells from human Jurkat cells with this device. It can be envisaged that this method is potentially applicable to address many biological and biomedical problems, especially those related to sample preparation.