Development of UV Spectrophotometric method for the simultaneous estimation of Simvastatine and Ezetimibe in tablet dosage form by simultaneous Equation and Absorbance ratio method.

versatile, accurate, precise and economic method for simultaneous determination of simvastatin and ezetimibe in fixed dose combination products was developed. The absorbance values at 238.2 nm and 247.6 nm and 243.3nm (isoabsorptive point) were used for the estimation of simvastatin and ezetimibe, respectively without mutual interference. This method obeyed Beer's law in the concentration range of 3-18 μg /ml for simvastatin and 5-30 μg /ml for ezetimibe. The results of analyses have been validated statistically for linearity, accuracy and precision, LOD and LOQ of the proposed method. Keywords: Simvastatin (SMV), Ezetimibe (EZE), methanol, distilled water, Simultaneous equation method, Absorption ratio method.