2015•Research Journal of Pharmaceutical Biological and Chemical SciencesRequires access
Comparative Study of the Effect of Diacerein and Diclofenac Sodium and Their Combination in Osteoarthritis Model Induced By Monoiodoacetate in Albino Rats.
Walla’a A Osman, Salwa Abd El Monaem Elmessiry, Olfat Shaker, Iman Zaki, Marian Youssry Wissa, Mohammed Amer, Ashraf Ali Shamaa
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Abstract
Osteoarthritis (OA) is the most common joint disorder. The current treatment of osteoarthritis is primarily focused on symptomatic relief by the use of rapidly acting analgesics such as NSAIDs and newer cyclooxygenase-2 (COX-2) specific inhibitors. Diacerein, an Interleukin-1β-antagonist that has been used in the last few years in the treatment of OA. This work was designed to compare the anti-inflammatory effect of Diacerein with Diclofenac Sodium and their combination on albino rats model of osteoarthritis. Ninety adult healthy female albino rats were allocated into 5 groups: normal untreated animals (negative control), the disease model group that received a single dose of monoiodoacetate (MIA) intra articularly in their right knees (positive control), and the (MIA) induced osteoarthritis treated either by Diacerein, diclofenac sodium, or their combination for 6 weeks. Level of serum cartilage oligomeric matrix protein, histopathological examination,