Effects of Kangyan Decoction-1 on Th1/Th2 cytokine in peripheral blood of patients with atopic dermatitis in wet-heat syndrome.

Objective:To investigate the effects of Kangyan Decoction-1 on Th1/Th2 in peripheral blood of patients with atopic dermatitis in wet-heat syndrome.Methods:The patients of atopic dermatitis were randomly divided into two groups: the therapy group treated with Kangyan Decoction-1 and the control group treated with loratadine.At the same time,the healthy nornal group was established,taking no medicine.The people's peripheral blood of three groups were detected respectively by flow cytometry.Results:Before the treatment,the level Th1 cell and the ratio of Th1/Th2 was augmented,the Th2 cell was decreased obviously of the therapy group(P0.01);the level of Th1 was no significant difference between the therapy group and the contral group(P0.05),the percentage of Th2 and the ratio of Th1/Th2 had statistic discrepancy(P0.05 or P0.01);the percentage of Th1,Th2 cell and the ratio of Th1/Th2 in peripheral blood of the therapy group and the control group,compared to the normal group,they had significant difference(P0.01).After the treatment,the percentage of Th1 and the ratio of Th1/Th2 of the therapy group,compared to normal group,had statistic discrepancy(P0.01);The level of Th2 had no significant difference (P0.05).Conclusion:The imbalance of Th1/Th2 might be part of the immune character of patients with atopic dermatitis in wet-heat syndrome.Kangyan Decoction-1 could adjust the Th1 and Th2 cells,but especially reduce the level of Th2 cell,adjusting the imbalance of Th1/Th2.This might be one of the possible function mechanism.