Marcel Hollenstein, Daniel Gautschi, Christian J. Leumann
Abstract
The fluorinated olefinic peptide nucleic acid analogue (F-OPA) monomer containing the base thymine was synthesised in 13 steps. PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting experiments.
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The fluorinated olefinic peptide nucleic acid analogue (F-OPA) monomer containing the base thymine was synthesised in 13 steps. PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting experiments.
Key concepts: Nucleic acid, Peptide nucleic acid, Thymine, Monomer, Nucleic acid analogue, Peptide, Chemistry, Base (topology)