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2004•Nucleosides Nucleotides & Nucleic AcidsRequires access

Binding Properties of the Conjugates of Oligo(2′‐O‐Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA

Д. С. Новопашина, Alexander N. Sinyakov, Vladimir A. Ryabinin, Alya G. Venyaminova, Loı̈c Perrouault, Erika Brunet, Carine Giovannangeli, Alexandre S. Boutorine

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Abstract

Design, synthesis, physico-chemical and in vitro biological studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with oligocarboxamide minor groove binders (MGB) and benzoindoloquinoline intercalator (BIQ) are described. These conjugates formed stable triple helices with the target double-stranded DNA and inhibited its in vitro transcription upon binding.

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What this paper is about

Design, synthesis, physico-chemical and in vitro biological studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with oligocarboxamide minor groove binders (MGB) and benzoindoloquinoline intercalator (BIQ) are described. These conjugates formed stable triple helices with the target double-stranded DNA and inhibited its in vitro transcription upon binding.

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Available abstract

Design, synthesis, physico-chemical and in vitro biological studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with oligocarboxamide minor groove binders (MGB) and benzoindoloquinoline intercalator (BIQ) are described. These conjugates formed stable triple helices with the target double-stranded DNA and inhibited its in vitro transcription upon binding.

Key concepts: Minor groove, Double stranded, Conjugate, DNA, In vitro, Chemistry, Intercalation (chemistry), Triple helix

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Binding Properties of the Conjugates of Oligo(2′‐O‐Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA — Research Paper | ScholarLens