2006Unpublished venueRequires access

Dendrimers in medicine and biotechnology new molecular tools

Ulrik Boas, Jesper B. Christensen, Peter M. H. Heegaard

Open publisher page 117 citations

Abstract

Chapter 1: Dendrimers: Design, synthesis and chemical properties 1.1: Introduction 1.2: Terms and nomenclature in dendrimer chemistry 1.3: Dendrimer design 1.4: Dendrimer synthesis 1.5: Physicochemical properties of dendrimers 1.6: Summary Chapter 2: Properties of dendrimers in biological systems 2.1: Significance of multivalent binding in biological interactions 2.2: Biocompatibility of dendrimers 2.3: Summary Chapter 3: Dendrimers as drug delivery devices 3.1: Introduction 3.2: Dendrimer hosts 3.3: Covalently bound dendrimer conjugates 3.4: Dendrimers as gene transfer reagents 3.5: Summary Chapter 4: Dendrimer drugs 4.1: Introduction 4.2: Antiviral dendrimers 4.3: Antibacterial dendrimers 4.4: Dendrimers in antitumor therapy 4.5: Dendrimer in therapy of other diseases 4.6: Dendrimer based vaccines 4.7: Dendrimer interactions with proteins. Solubilisation of protein aggregates 4.7: Summary Chapter 5: Dendrimers in diagnostics 5.1: Contrast agents based on dendrimers 5.2: Fluorescence enhanced by dendrimers 5.3: Dendrimers in bioassays 5.4: Summary Chapter 6: Dendrimers as biomimics 6.1: Introduction 6.2: Deddrimers as protein mimics 6.3: Dendrimers as artificial enzymes 6.4: Dendrimers as artificial antigens, antibodies and cell surfaces 6.5: Summary

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Chapter 1: Dendrimers: Design, synthesis and chemical properties 1.1: Introduction 1.2: Terms and nomenclature in dendrimer chemistry 1.3: Dendrimer design 1.4: Dendrimer synthesis 1.5: Physicochemical properties of dendrimers 1.6: Summary Chapter 2: Properties of dendrimers in biological systems 2.1: Significance of multivalent binding in biological interactions 2.2: Biocompatibility of dendrimers 2.3: Summary Chapter 3: Dendrimers as drug delivery devices 3.1: Introduction 3.2: Dendrimer hosts 3.3: Covalently bound dendrimer conjugates 3.4: Dendrimers as gene transfer reagents 3.5: Summary Chapter 4: Dendrimer drugs 4.1: Introduction 4.2: Antiviral dendrimers 4.3: Antibacterial dendrimers 4.4: Dendrimers in antitumor therapy 4.5: Dendrimer in therapy of other diseases 4.6: Dendrimer based vaccines 4.7: Dendrimer interactions with proteins. Solubilisation of protein aggregates 4.7: Summary Chapter 5: Dendrimers in diagnostics 5.1: Contrast agents based on dendrimers 5.2: Fluorescence enhanced by dendrimers 5.3: Dendrimers in bioassays 5.4: Summary Chapter 6: Dendrimers as biomimics 6.1: Introduction 6.2: Deddrimers as protein mimics 6.3: Dendrimers as artificial enzymes 6.4: Dendrimers as artificial antigens, antibodies and cell surfaces 6.5: Summary

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Available abstract

Chapter 1: Dendrimers: Design, synthesis and chemical properties 1.1: Introduction 1.2: Terms and nomenclature in dendrimer chemistry 1.3: Dendrimer design 1.4: Dendrimer synthesis 1.5: Physicochemical properties of dendrimers 1.6: Summary Chapter 2: Properties of dendrimers in biological systems 2.1: Significance of multivalent binding in biological interactions 2.2: Biocompatibility of dendrimers 2.3: Summary Chapter 3: Dendrimers as drug delivery devices 3.1: Introduction 3.2: Dendrimer hosts 3.3: Covalently bound dendrimer conjugates 3.4: Dendrimers as gene transfer reagents 3.5: Summary Chapter 4: Dendrimer drugs 4.1: Introduction 4.2: Antiviral dendrimers 4.3: Antibacterial dendrimers 4.4: Dendrimers in antitumor therapy 4.5: Dendrimer in therapy of other diseases 4.6: Dendrimer based vaccines 4.7: Dendrimer interactions with proteins. Solubilisation of protein aggregates 4.7: Summary Chapter 5: Dendrimers in diagnostics 5.1: Contrast agents based on dendrimers 5.2: Fluorescence enhanced by dendrimers 5.3: Dendrimers in bioassays 5.4: Summary Chapter 6: Dendrimers as biomimics 6.1: Introduction 6.2: Deddrimers as protein mimics 6.3: Dendrimers as artificial enzymes 6.4: Dendrimers as artificial antigens, antibodies and cell surfaces 6.5: Summary

Key concepts: Dendrimer, Chemistry, Combinatorial chemistry, Nanotechnology, Biophysics, Materials science, Organic chemistry, Biology

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