2011•Clinical Infectious DiseasesOpen access

Additional Drug Resistance in Mycobacterium tuberculosis Isolates From Resected Cavities Among Patients With Multidrug-Resistant or Extensively Drug-Resistant Pulmonary Tuberculosis

Russell Ryan Kempker, Alexander S. Rabin, Ketino Nikolaishvili, Iagor Kalandadze, Shota Gogishvili, Henry M. Blumberg, Sergo A. Vashakidze

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Abstract

The pathogenesis of increasing drug resistance among patients with multidrug-resistant or extensively drug-resistant tuberculosis undergoing treatment is poorly understood. Increasing drug resistance found among Mycobacterium tuberculosis recovered from cavitary isolates compared with paired sputum isolates suggests pulmonary cavities may play a role in the development of worsening tuberculosis drug resistance.

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Key concepts: Medicine, Tuberculosis, Drug resistance, Mycobacterium tuberculosis, Sputum, Multiple drug resistance, Drug, Extensively drug-resistant tuberculosis