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Trichosanthin, α‐momorcharin and β‐momorcharin: identity of abortifacient and ribosome‐inactivating proteins

Hin Wing Yeung, Wai Wan Li, Feng Zhang, Luigi Barbieri, Fiorenzo Stirpe

Open publisher page 96 citations

Abstract

The abortifacient proteins trichosanthin, alpha-momorcharin and beta-momorcharin at nM concentrations inhibit cell-free protein synthesis. The momorcharins and the ribosome-inactivating proteins isolated from Momordica charantia seeds cross-react with the respective antisera. The ribosome-inactivating proteins saporins, pokeweed antiviral protein (PAP) and, to a lesser extent, gelonin have abortifacient activity on pregnant mice.

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What this paper is about

The abortifacient proteins trichosanthin, alpha-momorcharin and beta-momorcharin at nM concentrations inhibit cell-free protein synthesis. The momorcharins and the ribosome-inactivating proteins isolated from Momordica charantia seeds cross-react with the respective antisera. The ribosome-inactivating proteins saporins, pokeweed antiviral protein (PAP) and, to a lesser extent, gelonin have abortifacient activity on pregnant mice.

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OpenAlex reports 96 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The abortifacient proteins trichosanthin, alpha-momorcharin and beta-momorcharin at nM concentrations inhibit cell-free protein synthesis. The momorcharins and the ribosome-inactivating proteins isolated from Momordica charantia seeds cross-react with the respective antisera. The ribosome-inactivating proteins saporins, pokeweed antiviral protein (PAP) and, to a lesser extent, gelonin have abortifacient activity on pregnant mice.

Key concepts: Trichosanthin, Ribosome-inactivating protein, Momordica, Antiserum, Ribosome, Abortifacient, Saporin, Chemistry

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