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2004•Chinese Journal of Coll BiologyRequires access

Ribosome-inactivating Proteins in Bitter Gourd (Momordica charantia)

Sun Hai

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Abstract

Ribosome-inactivating proteins (RIPs) are a group of protein toxins that inhibit protein synthesis by cleaving the largest rRNA of ribosomes. RIPs can be classified into two types, Type Ⅰ and type Ⅱ RIP. Several Type Ⅰ RIPs, including α-Momorharin, β-Momorcharin and MAP30 have been identified in Momordica charantia. The antitumor, antiviral and anti-AIDS properties of these proteins have aroused wide interest in this area. Progress in the study of RIPs in bitter gourd and its application are reviewed in this paper.

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What this paper is about

Ribosome-inactivating proteins (RIPs) are a group of protein toxins that inhibit protein synthesis by cleaving the largest rRNA of ribosomes. RIPs can be classified into two types, Type Ⅰ and type Ⅱ RIP. Several Type Ⅰ RIPs, including α-Momorharin, β-Momorcharin and MAP30 have been identified in Momordica charantia. The antitumor, antiviral and anti-AIDS properties of these proteins have aroused wide interest in this area. Progress in the study of RIPs in bitter gourd and its application are reviewed in this paper.

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Available abstract

Ribosome-inactivating proteins (RIPs) are a group of protein toxins that inhibit protein synthesis by cleaving the largest rRNA of ribosomes. RIPs can be classified into two types, Type Ⅰ and type Ⅱ RIP. Several Type Ⅰ RIPs, including α-Momorharin, β-Momorcharin and MAP30 have been identified in Momordica charantia. The antitumor, antiviral and anti-AIDS properties of these proteins have aroused wide interest in this area. Progress in the study of RIPs in bitter gourd and its application are reviewed in this paper.

Key concepts: Momordica, Ribosome-inactivating protein, Bitter gourd, Biology, Ribosome, Biochemistry, Cucurbitaceae, Ribosomal RNA

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