2013•South African Journal of ChemistryOpen access

A simple three-component synthesis of 3-amino-5-arylpyridazine-4-carbonitriles

Jabbar Khalafy, Mehdi Rimaz, Saghar Farajzadeh, Mahnaz Ezzati

Abstract

New 3-amino-5-arylpyridazine-4-carbonitriles have been synthesized by a one-pot three-component reaction of malononitrile with arylglyoxals in the presence of hydrazine hydrate at room temperature in water and ethanol. KEYWORDS Arylglyoxals, arylpyridazines, hydrazine hydrate, one-pot, malononitrile.

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Available abstract

Key concepts: Malononitrile, Hydrazine (antidepressant), Hydrate, Chemistry, Component (thermodynamics), Ethanol, Organic chemistry, Chromatography