2010•Synthetic CommunicationsRequires access
Glycine-Catalyzed Efficient Synthesis of Pyranopyrazoles via One-Pot Multicomponent Reaction
M. B. Madhusudana Reddy, V. P. Jayäshankara, M. A. Päsha
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Abstract
A facile and convenient protocol is developed for the fast (5–20 min) and high-yielding (85–95%) synthesis of fused pyranopyrazoles from ethyl acetoacetate, hydrazine hydrate, an aldehyde, and malononitrile in the presence of nontoxic, simple, and readily available organocatalyst glycine in aqueous medium at 25 °C.