Stress Proteins and Sirs-Sepsis The Possible Roles of Heat Shock Proteins (HSP’s) in The Development of Systemic Inflammatory Response Syndrome (SIRS)

Systemic Inflammatory Response Syndrome (SIRS) was first recognized as a separate clinical entity when invading micro-organism which first caused a local inflammation overwhelmed our body’s defenses and began to invade the blood stream causing a much graver systemic condition, often endangering the patient’s life. It was then known variously as sepsis or septicaemia. When it became clear that the same systemic response could be elicited by other conditions other than microbial invasion a new term was coined systemic inflammatory response syndrome (SIRS)