1995•Clinical Pulmonary MedicineRequires access
Systemic Inflammatory Response Syndrome (SIRS)
Alan M. Fein
Open publisher page 0 citations
Abstract
Synopsis: Systemic inflammatory response syndrome (SIRS) has been recently hypothesized to develop along a continuum of inflammatory reaction to injury. Wlien this process is initiated by infection, it is termed sepsis. To evaluate the components of the progressive inflammatory response to infection and to test the validity of the “SIRS” hypothesis, Rangel-Frausto and coworkers prospectively evaluated 2527 patients who met criteria for SIRS. They confirmed a progression of inflammatory response of increasing severity, which expressed itself in a stepwise fashion as sepsis, severe sepsis, and septic shock. With each step, organ failure and mortality increased. SOURCES: Rangel-Frausto MS, Pittet D, Costigan M, et al. The natural history of the systemic inflammatory response syndrome (SIRS). JAMA 1995;273:117–23.