2000•FEMS Microbiology LettersRequires access

Genetic analysis of SecA–SecY interaction required for spore development inBacillus subtilis

Hitomi Kobayashi, Yoshiaki Ohashi, Hideaki Nanamiya, Kei Asai, Fujio Kawamura

Abstract

All spontaneous suppressor mutations obtained from a secA12 sporulation-defective mutant in Bacillus subtilis were localized in highly conserved membrane-spanning regions of SecY. The expression of early sporulation genes, kinA and spo0A encoding a histidine kinase and a transcription regulator for several sporulation genes, respectively, was restored in these suppressor mutants. These results indicate that the secretion function of translocase combined with Sec proteins is required for sporulation in B. subtilis.

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Key concepts: Bacillus subtilis, Translocase, Mutant, Biology, Gene, Response regulator, Histidine kinase, Transcription (linguistics)