A Note on the Antifungal Activity of Pentachlorophenyl Dodecanoate

Abstract The antifungal activity of pentachlorophenyl dodecanoate against certain dermatophytes has been studied. The substance, in Sabouraud's maltose agar in 2 per cent concentration, inhibited the growth of Microsporum canis, Trichophyton interdigitale, Trichophyton rubrum, and Microsporum audouini. No activity was observed against Candida albicans, and only a slight inhibition in the growth of Epidermophyton floccosum. A 3 per cent concentration of the ester in an ointment base effected complete inhibition of Trichophyton interdigitale and Microsporum canis alone, and in mixed cultures.