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A STUDY OF INTERMEDIATE CARBOHYDRATE METABOLISM IN RATS EXPOSED TO HIGH OXYGEN PRESSURES

Ellen R. Gordon, David O. Tinker, William J. Watson

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Abstract

Exposure of male rats to 100% oxygen at 6 atmospheres for 20 minutes produced an increase in the concentration of fructose-1,6-diphosphate in the liver and muscle, but not in the brain. The activities of aldolase and glyceraldehyde phosphate dehydrogenase were measured in the liver and muscle. The change in the activity of these enzymes indicated that they had not become rate-limiting during exposure. The relation of these data to the Pasteur effect is considered.

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Exposure of male rats to 100% oxygen at 6 atmospheres for 20 minutes produced an increase in the concentration of fructose-1,6-diphosphate in the liver and muscle, but not in the brain. The activities of aldolase and glyceraldehyde phosphate dehydrogenase were measured in the liver and muscle. The change in the activity of these enzymes indicated that they had not become rate-limiting during exposure. The relation of these data to the Pasteur effect is considered.

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Available abstract

Exposure of male rats to 100% oxygen at 6 atmospheres for 20 minutes produced an increase in the concentration of fructose-1,6-diphosphate in the liver and muscle, but not in the brain. The activities of aldolase and glyceraldehyde phosphate dehydrogenase were measured in the liver and muscle. The change in the activity of these enzymes indicated that they had not become rate-limiting during exposure. The relation of these data to the Pasteur effect is considered.

Key concepts: Aldolase A, Oxygen, Oxygen metabolism, Metabolism, Dehydrogenase, Fructose-bisphosphate aldolase, Fructose, Glyceraldehyde

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