2006•Antimicrobial Agents and ChemotherapyOpen access

Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus

Longzhu Cui, Eiji Tominaga, Hui‐min Neoh, Keiichi Hiramatsu

Abstract

We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus.

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Key concepts: Daptomycin, Vancomycin, Staphylococcus aureus, Microbiology, Staphylococcal infections, Micrococcaceae, Antibacterial agent, Antibiotics