2006•Antimicrobial Agents and ChemotherapyOpen access

Induction of Daptomycin Heterogeneous Susceptibility in Staphylococcus aureus by Exposure to Vancomycin

George Sakoulas, Jeff Alder, C Thauvin-Eliopoulos, Robert C. Moellering, George M. Eliopoulos

Abstract

We studied vancomycin and daptomycin susceptibility in methicillin-resistant Staphylococcus aureus from patients exposed to vancomycin, glycopeptide-intermediate S. aureus, and S. aureus passaged in vancomycin-containing medium. A correlation between vancomycin and daptomycin heteroresistance was noted in some strains, suggesting that exposure of S. aureus to vancomycin may affect susceptibility to daptomycin.

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Key concepts: Daptomycin, Vancomycin, Staphylococcus aureus, Glycopeptide, Microbiology, Antibiotics, Micrococcaceae, Glycopeptide antibiotic