2004•American Journal of Physiology-Gastrointestinal and Liver PhysiologyRequires access

Gastrointestinal Satiety Signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide

Sarah A. Stanley, Katie Wynne, Steve Bloom

Abstract

Many peptides are synthesized and released from the gastrointestinal tract and pancreas, including pancreatic polypeptide (PP) and the products of the gastrointestinal L cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY). Whereas their roles in regulation of gastrointestinal function have been known for some time, it is now evident that they also influence eating behavior. This review considers the anorectic peptides PYY, PP, GLP-1, and oxyntomodulin, which decrease appetite and promote satiety in both animal models and humans.

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Key concepts: Peptide YY, Pancreatic polypeptide, Anorectic, Appetite, Internal medicine, Gastrointestinal function, Glucagon-like peptide-1, Endocrinology