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1999•International Journal of Psychiatry in Clinical PracticeRequires access

Adjunctive use of olanzapine in the treatment of mania

Peter Haddad, Imran B. Chaudhry, Som D. Soni

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Abstract

Olanzapine is an atypical antipsychotic which is licensed only for the treatment of schizophrenia. Two cases are described in which olanzapine was used (IS an adjunct to lithium in treating mania in patients with bipolar disorder. In both cases the lithium-olanzapine combination was more effective and better tolerated than a previous combination of lithium with a traditional antipsychotic. Olanzapine may offer significant advantages over traditional antipsychotics in the treatment of mania, but controlled trials are needed to confirm this.

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What this paper is about

Olanzapine is an atypical antipsychotic which is licensed only for the treatment of schizophrenia. Two cases are described in which olanzapine was used (IS an adjunct to lithium in treating mania in patients with bipolar disorder. In both cases the lithium-olanzapine combination was more effective and better tolerated than a previous combination of lithium with a traditional antipsychotic. Olanzapine may offer significant advantages over traditional antipsychotics in the treatment of mania, but controlled trials are needed to confirm this.

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Available abstract

Olanzapine is an atypical antipsychotic which is licensed only for the treatment of schizophrenia. Two cases are described in which olanzapine was used (IS an adjunct to lithium in treating mania in patients with bipolar disorder. In both cases the lithium-olanzapine combination was more effective and better tolerated than a previous combination of lithium with a traditional antipsychotic. Olanzapine may offer significant advantages over traditional antipsychotics in the treatment of mania, but controlled trials are needed to confirm this.

Key concepts: Olanzapine, Mania, Lithium (medication), Antipsychotic, Schizophrenia (object-oriented programming), Bipolar disorder, Psychiatry, Atypical antipsychotic

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