2012•Journal of Clinical MicrobiologyOpen access
A Reliable and Reproducible Experimental Challenge Model for Peste des Petits Ruminants Virus
Mehdi El Harrak, Nadia Touil, Chafiqua Loutfi, Mustapha Hammouchi, Satya Parida, Gizlane Sebbar, Nadia Chaffai, Bachir Harif, Nezha Messoudi, Carrie Batten, Chris Oura
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Abstract
Experimental challenge protocols that consistently reproduce clinical signs of peste des petits ruminants in Alpine goats infected with a tissue culture-passaged peste des petits ruminants virus are described. The protocols can be used to carry out quality-controlled vaccine efficacy and pathogenesis studies under experimental conditions.