2005•PubMedOpen access

Elevated cyclooxygenase-2 expression is associated with histological grade in invasive ductal breast carcinoma.

Emiko Takeshita, Takayuki Osanai, Tetsuro Higuchi, Labile Togba Soumaoro, Kenichi Sugihara

Abstract

PURPOSE: The aim of this study was to evaluate the expression of cyclooxygenase-2 in human breast cancer using immunohistochemistry and to determine whether the expression of cyclooxygenase-2 is associated with clinicopathological factors in invasive ductal breast carcinoma. METHODS: Cyclooxygenase-2 expression was investigated by immunohistochemistry in 30 invasive ductal breast carcinoma specimens and relationships between cyclooxygenase-2 expression and age, histological grade, histological type, nodal status, and hormone receptor status were evaluated. RESULTS: Cyclooxygenase-2 expression was found in 56.7% of the tumor samples and was related to histological grade (P<0.01) and histological type (P<0.001). CONCLUSIONS: Our results suggest that cyclooxygenase-2 expression has an important role in tumor differentiation in invasive ductal breast carcinoma.

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Key concepts: Cyclooxygenase, Immunohistochemistry, Medicine, Pathology, Breast cancer, Invasive ductal carcinoma, Breast carcinoma, Ductal carcinoma