1985•Infection and ImmunityOpen access

Pattern of formylmethionyl-leucyl-phenylalanine-induced luminol- and lucigenin-dependent chemiluminescence in human neutrophils

Cláes Dahlgren, H Aniansson, Karl‐Eric Magnusson

Abstract

The stimulation of neutrophils by formylmethionyl-leucyl-phenylalanine results in a bimodal luminol-dependent chemiluminescence pattern. We observed, however, only a single peak chemiluminescence pattern in the response to the peptide when we used lucigenin as an amplifying substance. We suggest that lucigenin, the larger molecule, (510 daltons; luminol is 177 daltons) only exerts an extracellular effect.

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Available abstract

Key concepts: Lucigenin, Luminol, Chemiluminescence, Stimulation, Extracellular, Chemistry, Phenylalanine, Biochemistry