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2008•HaematologicaOpen access

The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia

Tôru Kondo, Akio Mori, Stephanie Darmanin, S. Hashino, Junji Tanaka, Masahiro Asaka

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Abstract

The majority of acute promyelocytic leukemia (APL) cases are characterized by the expression of the chimeric fusion gene PML-RARA . Although the PML-RARA fusion gene is detected in more than 95% of APL cases, RARA has also been found to fuse with other partner genes in some APL variants. To date,

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What this paper is about

The majority of acute promyelocytic leukemia (APL) cases are characterized by the expression of the chimeric fusion gene PML-RARA . Although the PML-RARA fusion gene is detected in more than 95% of APL cases, RARA has also been found to fuse with other partner genes in some APL variants. To date,

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Available abstract

The majority of acute promyelocytic leukemia (APL) cases are characterized by the expression of the chimeric fusion gene PML-RARA . Although the PML-RARA fusion gene is detected in more than 95% of APL cases, RARA has also been found to fuse with other partner genes in some APL variants. To date,

Key concepts: Acute promyelocytic leukemia, Fusion gene, Medicine, Leukemia, Gene, Immunology, Cancer research, Virology

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The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia — Research Paper | ScholarLens