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2023•BloodOpen access

Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia

Qi Zhang, He Li, Xuelan Chen, Fan Gu, Lanxin Zhang, Lu Zhang, Tong Chen, Qiang Chen, Wentong Meng, Yu Wu, Hong Chang, Ting Liu, Chong Chen, Hongbing Ma, Yu Liu

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Abstract

Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.

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What this paper is about

Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.

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Available abstract

Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.

Key concepts: Acute promyelocytic leukemia, Fusion gene, Leukemia, Retinoic acid, Cancer research, Medicine, Tretinoin, Gene

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