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2014•Beilstein Journal of Organic ChemistryOpen access

Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics

Tatyana V. Abramova, Sergey S Belov, Yulia V Tarasenko, Vladimir N. Silnikov

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Abstract

An efficient solid-phase-supported peptide synthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as first subunits.

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An efficient solid-phase-supported peptide synthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as first subunits.

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Available abstract

An efficient solid-phase-supported peptide synthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as first subunits.

Key concepts: Chemistry, Oligonucleotide, Linker, Solid-phase synthesis, Oligonucleotide synthesis, Combinatorial chemistry, Residue (chemistry), Nucleoside

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