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2011•Bioorganic & Medicinal Chemistry LettersRequires access

New light labile linker for solid phase synthesis of 2′-O-acetalester oligonucleotides and applications to siRNA prodrug development

Richard Johnsson, Jeremy G. Lackey, Jovanka Bogojeski, Masad J. Damha

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Key concepts: Linker, Oligonucleotide, Prodrug, Chemistry, Solid-phase synthesis, Nucleic acid, Oligonucleotide synthesis, Combinatorial chemistry

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New light labile linker for solid phase synthesis of 2′-O-acetalester oligonucleotides and applications to siRNA prodrug development — Research Paper | ScholarLens