2014•SynlettOpen access

Organic Photoredox Catalysis as a General Strategy for Anti-Markovnikov Alkene Hydrofunctionalization

David A. Nicewicz, David Hamilton

Abstract

The development of a general catalyst system for the direct anti-Markovnikov hydrofunctionalization of alkenes is presented. A unique catalyst system comprised of an acridinium photooxidant and a hydrogen atom transfer reagent allows for a range of alkene anti-Markovnikov hydrofunctionalization reactions including hydroalkoxylation, hydroamination, and hydroacetoxylation.

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Available abstract

Key concepts: Markovnikov's rule, Chemistry, Alkene, Hydroamination, Catalysis, Combinatorial chemistry, Organic chemistry, Hydrogen atom