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2017•Asian Journal of Organic ChemistryRequires access

Iron‐Catalyzed Anti‐Markovnikov Hydroamination of Vinylpyridines

Yahui Peng, Cong Qin, Xiaobei Chen, Jianjun Li, Hao Li, Wei Wang

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Abstract

Abstract An efficient, green and atom‐economical iron‐catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti‐Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

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What this paper is about

Abstract An efficient, green and atom‐economical iron‐catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti‐Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

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Available abstract

Abstract An efficient, green and atom‐economical iron‐catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti‐Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.

Key concepts: Markovnikov's rule, Hydroamination, Chemistry, Catalysis, Toluene, Organic chemistry, Combinatorial chemistry, Regioselectivity

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