2000•Antimicrobial Agents and ChemotherapyOpen access

Mechanisms of Resistance to Quinupristin-Dalfopristin among Isolates of Enterococcus faecium from Animals, Raw Meat, and Hospital Patients in Western Europe

Mehnam Soltani, D. Beighton, John Philpott‐Howard, Neil Woodford

Abstract

Twenty-eight quinupristin-dalfopristin-resistant isolates of Enterococcus faecium from hospital patients and nonhuman sources in European countries were studied. High-level resistance (MICs, >/=32 microg/ml) was associated with the presence of vat(E) (satG) (14 isolates ¿50%) or vat(D) (satA) (6 isolates ¿21%). These genes were not detected in eight (29%) isolates with lower levels of quinupristin-dalfopristin resistance (MICs, 4 to 16 microg/ml). This suggests the presence of further mechanisms of resistance to quinupristin-dalfopristin in E. faecium.

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Key concepts: Quinupristin, Enterococcus faecium, Dalfopristin, Biology, Virginiamycin, Microbiology, Enterococcus, Antibiotics