Pharmacokinetics and Distribution of Florfenicol in Bronchial Secretions of Healthy and Pasteurella multocida Infected Calves

Animals and husbandryTen calves aged one-and-a-half month and weighing from 65 to 75 kg were used in the experimental work.The calves were housed individually in adjacent boxes that had a floor area of 4 m 2 and a volume of 6 m 3. The animals were bedded on straw.During acclimatization for one week and the subsequent treatment periods, calves were fed on milk replacer (free of antimicrobial substances, twice daily at 09.00 and 18.00) and alfalfa with drinking water available ad libitum.The animals were shaved over jugular vein to facilitate the collection of blood samples.