2003•Antimicrobial Agents and ChemotherapyOpen access

Interactions of 1263W94 with Other Antiviral Agents in Inhibition of Human Cytomegalovirus Replication

Dean W. Selleseth, Christine L. Talarico, Teresa Miller, Michael William Lutz, Karen K. Biron, Robert J. Harvey

Abstract

Inhibition of human cytomegalovirus (HCMV) by 1263W94 was additive dosewise in combination with ganciclovir, acyclovir, and foscarnet. None of the commonly used anti-human immunodeficiency virus agents antagonized the inhibition of HCMV by 1263W94. The data were analyzed by a modified isobologram procedure that measures the strength and statistical significance of drug interactions.

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Available abstract

Key concepts: Foscarnet, Ganciclovir, Human cytomegalovirus, Virology, Cytomegalovirus, Viral replication, Replication (statistics), Lentivirus