1990•Antimicrobial Agents and ChemotherapyOpen access

Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro

Jody F. Manischewitz, Gerald V. Quinnan, H. Clifford Lane, Alec E. Wittek

Abstract

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.

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Available abstract

Key concepts: Foscarnet, Ganciclovir, Cytomegalovirus, Toxicity, Pharmacology, Virology, Human cytomegalovirus, In vitro