1999•Journal of Clinical MicrobiologyOpen access

Interactions between Methicillin and Vancomycin in Methicillin-Resistant Staphylococcus aureus Strains Displaying Different Phenotypes of Vancomycin Susceptibility

Robin Howe, Mandy Wootton, Peter M. Bennett, Alasdair MacGowan, Timothy R. Walsh

Abstract

Vancomycin-sensitive, -intermediate, and -heterointermediate methicillin-resistant Staphylococcus aureus isolates were tested by using E-tests to explore the interaction of methicillin and vancomycin. For the vancomycin-intermediate and -heterointermediate strains both drugs showed antagonism at concentrations below their MICs but synergy at methicillin concentrations near the MIC. This property could be used to screen for heterointermediate S. aureus strains.

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Key concepts: Vancomycin, Staphylococcus aureus, Microbiology, Methicillin-resistant Staphylococcus aureus, Antagonism, Micrococcaceae, Antibiotics, Staphylococcal infections