2013•Future MicrobiologyOpen access

Elucidating the Immunological Function of the Cryptococcus Neoformans Capsule

Anna Vecchiarelli, Eva Pericolini, Elena Gabrielli, Samyr Kenno, Stefano Perito, Elio Cenci, Claudia Monari

Abstract

The encapsulated fungal pathogen Cryptococcus neoformans represents a significant agent of life-threatening infections in immunocompromised subjects. A unique characteristic of Cryptococcus species is the presence of a polysaccharide capsule, which is essential for virulence and endows Cryptococcus with potent immunoregulatory properties. This review provides an overview of the immunological properties of the principal components of C. neoformans capsule.

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Key concepts: Cryptococcus neoformans, Cryptococcus, Microbiology, Fungal pathogen, Biology, Virulence, Capsule, Cryptococcosis