Transcription factors and target genes relationship based method reveals potential thermal injury related genes

Thermal injury to the skin can induce local and systemic perturbations that are costly in terms of human suffering as well as in strains on the health care system. We used the GSE8056 microarray data to identify potential genes related to burn wound to construct a regulation network. In the network, some of transcription factors (TFs) and target genes have been proved that are related to burn wound in previous study. We also find some new TFs and target genes response to thermal injury, such as EGLN3 and CREM. It is demonstrated that transcriptome network analysis is useful in identification of the candidate genes in thermal injury.   Key words: Transcription factors, genes, thermal injury, transcriptome network.