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2006•Journal of Biomedical OpticsOpen access

Collagen solubility correlates with skin optical clearing

Jason M. Hirshburg, Bernard Choi, J. Stuart Nelson, Alvin T. Yeh

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Abstract

Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.

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What this paper is about

Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.

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OpenAlex reports 94 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Biomedical optics and photomedicine applications are challenged by the turbidity of most biological tissue systems. Nonreactive, biocompatible chemical agents can induce a reversible reduction in optical scattering of collagenous tissues such as human skin. Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations.

Key concepts: Biocompatible material, Solubility, Materials science, Biomedical engineering, Biocompatibility, Nanotechnology, Chemistry, Biophysics

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Collagen solubility correlates with skin optical clearing — Research Paper | ScholarLens