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2010•Antimicrobial Agents and ChemotherapyOpen access

In Vitro Antibiotic Synergy in Extensively Drug-Resistant Acinetobacter baumannii : the Effect of Testing by Time-Kill, Checkerboard, and Etest Methods

Thean Yen Tan, Tze Peng Lim, Winnie Hui Ling Lee, Suranthran Sasikala, Li Yang Hsu, Andrea Lay‐Hoon Kwa

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Abstract

This study examined the in vitro effects of polymyxin B, tigecycline, and rifampin combinations on 16 isolates of extensively drug-resistant Acinetobacter baumannii, including four polymyxin-resistant strains. In vitro synergy was demonstrated in 19 (40%) of a possible 48 isolate-antibiotic combinations by time-kill methods, 8 (17%) by checkerboard methods, and only 1 (2%) by Etest methods. There was only slight agreement between Etest and checkerboard methods and no agreement between results obtained by other methods.

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What this paper is about

This study examined the in vitro effects of polymyxin B, tigecycline, and rifampin combinations on 16 isolates of extensively drug-resistant Acinetobacter baumannii, including four polymyxin-resistant strains. In vitro synergy was demonstrated in 19 (40%) of a possible 48 isolate-antibiotic combinations by time-kill methods, 8 (17%) by checkerboard methods, and only 1 (2%) by Etest methods. There was only slight agreement between Etest and checkerboard methods and no agreement between results obtained by other methods.

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Available abstract

This study examined the in vitro effects of polymyxin B, tigecycline, and rifampin combinations on 16 isolates of extensively drug-resistant Acinetobacter baumannii, including four polymyxin-resistant strains. In vitro synergy was demonstrated in 19 (40%) of a possible 48 isolate-antibiotic combinations by time-kill methods, 8 (17%) by checkerboard methods, and only 1 (2%) by Etest methods. There was only slight agreement between Etest and checkerboard methods and no agreement between results obtained by other methods.

Key concepts: Etest, Checkerboard, Acinetobacter baumannii, Tigecycline, Microbiology, Antibiotics, Polymyxin, Polymyxin B

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