Computer biochemistry and molecular physiology of the natural peptide ligands: different functional groups

The similarity in the functional spectra of many endogenous regulatory oligopeptides [1] allows the assumption that these molecules possess some common physicochemical properties. These properties provide the basis for the interaction of an oligopeptide with a particular set of receptor structures, and this interaction is the initial step of the functional response. Of great interest is therefore to reveal common chemical features of these molecules, in particular their size and specific radicals, protruding out of the peptide backbone. The principles of computer biochemistry were used [2].