1950•Experimental Biology and MedicineRequires access

Effects of Vitamin B12 on Thiouracil Action in Rats.

J. Meites

Abstract

The effects of crystalline vit. B12 on thiouracil action was determined in immature female rats for a 30-day period. The vitamin completely counteracted the growth-inhibiting action of thiouracil, and this was accompanied by a considerable increase in food consumption. Although vit. B12 decreased the thyroid hypertrophy induced by thiouracil, the uptake of radioactive iodine (I131) by the thyroids was even less than in the rats which received thiouracil only. It is suggested that vit. B12 may be able to induce normal growth in hypothyroid rats.

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Key concepts: Thiouracil, Endocrinology, Internal medicine, Vitamin B12, Thyroid, Iodine, Chemistry, Biology