Effect of Pretreatment with Propyl Thiouracil on Accumulation of Astatine211 by Thyroid Gland of the Rat
P.W. Durbin, Joseph G. Hamilton, Marshall W. Parrott
Abstract
P.W. Durbin, Joseph G. Hamilton, Marshall W. Parrott
Abstract
A study has been made of the accumulation of I131 and At211 in normal and propyl thiouracil-treated rats. A very marked enhancement of the accumulation of At211 in the thyriod gland has been observed following administration of propyl thiouracil. This is in contrast to the diminution of the uptake of I131 by the thyroid glands of the rats receiving propyl thiouracil.
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A study has been made of the accumulation of I131 and At211 in normal and propyl thiouracil-treated rats. A very marked enhancement of the accumulation of At211 in the thyriod gland has been observed following administration of propyl thiouracil. This is in contrast to the diminution of the uptake of I131 by the thyroid glands of the rats receiving propyl thiouracil.
Key concepts: Thiouracil, Thyroid, Endocrinology, Internal medicine, Chemistry, Biology, Medicine