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Additive Effect of the Combination of Griseofulvin and Ketoconazole Against Microsporum canis in Vitro: Additiver Effekt der Kombination von Griseofulvin und Ketoconazol gegen Microsporum canis in vitro

Stanko Banič, Majda Lunder

Abstract

Summary: The susceptibility of 28 strains of Microsporum canis to griseofulvin, to ketoconazole and to a combination of both antifungal drugs was determined. Griseofulvin proved to be more active than ketoconazole. The combination of both antifungal agents was found to exert an additive effect. Zusammenfassung: Die Sensibilität von 28 Stämmen von Microsporum canis für Griseofulvin, Ketoconazol und für eine Kombination von beiden Antimykotika wurde bestimmt. Griseofulvin war aktiver als Ketoconazol. Die Kombination von beiden Antimykotika zeigte einen additiven Effekt.

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Key concepts: Griseofulvin, Microsporum canis, Ketoconazole, Microsporum, Microbiology, Antifungal, In vitro, Pharmacology