Spectrophotometric Estimation of Mesalazine in Tablet Dosage Form

Three simple, precise and economical UV methods have been developed for the estimation of Mesalazine in tablet dosage form. Mesalazine has the absorbance maxima at 303.5 nm (Method A), and in the first order derivative spectra, showed sharp peak at 241.0 nm (Method B). Method C applied was area under curve (AUC) in the wavelength range of 308.5–298.5 nm. Linearity for detector response was observed in the concentration range of 10–50 μg/ml for all three methods. The proposed methods were successfully applied for the determination of Mesalazine in commercial tablet preparation. The results of the analysis were validated statistically and by recovery studies and were found to be satisfactory.