2009•Journal of BacteriologyOpen access

Feedback Regulation of Lac Repressor Expression inEscherichia coli

Stefan Oehler

Abstract

Negative feedback regulation, mediated through repressor binding site O3, which overlaps the lacI gene, could explain the robustness of the weak expression of Lac repressor. Significant autorepression of Lac repressor has never been ruled out. In the work presented here, the degree of autoregulation of Lac repressor was determined. It is negligible.

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Key concepts: Lac repressor, Repressor, Biology, lac operon, Autoregulation, Escherichia coli, Regulation of gene expression, YY1