1973•Proceedings of the National Academy of SciencesOpen access

A Mutant of Escherichia coli with a New, Highly Efficient Promoter for the Lactose Operon

Jeremy A. Bruenn, Helen M. Hollingsworth

Abstract

We have isolated a mutant of E. coli whose maximal rate of synthesis of lac mRNA is 25-fold greater than that of its parental wild-type strain. The mutant also shows alterations in the kinetics of beta-galactosidase synthesis, the functional half-life of beta-galactosidase mRNA, and the properties of lac repressor.

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Key concepts: Lac repressor, Mutant, Operon, lac operon, Escherichia coli, Beta-galactosidase, Repressor, trp operon