The treatment of cutaneous candidiasis in rabbits

Experimental cutaneous candidiasis of rabbits was suitable for assessing therapeusis. The polyene antibiotics natamycin, amphotericin B and nystatin showed considerable anticandidal activity. They were superior to the creams or lotions containing quinoline or 10% borax solutions. Gentian violet and bis-phenyl-(2-chlorophenyl)-1-imidazolylmethane were very effective. The topical application of hydrocortisone, neomycin or hexachlorophene favoured the development of the cutaneous candidiasis in rabbits. The influence of the preparations on skin-inhabiting bacteria was also determined. Natamycin seemed to differ in vitro from other polyenes in its mode of action.