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2016•Russian Journal of General ChemistryRequires access

Synthesis and biological activity of new hybrids compounds derived from benzofuroxanes and polyene antibiotics

Elena Chugunova, Rezeda E. Mukhamatdinova, Marina Sazykina, Ivan Sazykin, Margarita Khammami, Nurgali Akylbekov, А. Р. Бурилов, Natalia Kulik, В. В. Зобов

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Abstract

Hybrid compounds based on 4,6-dichloro-5-nitrobenzofuroxan, 7-chloro-4,6-dinitrobenzofuroxan, 5,7-dichloro-4,6-dinitrobenzofuroxan, and polyene antibiotics (amphotericin B and nystatin) have been prepared for the first time. They have exhibited biological activity comparable to that of starting antibiotics. Activity of the compound derived from 5,7-dichloro-4,6-dinitrobenzofuroxan and nystatin towards Trichophyton mentagrophytes is 4 times higher than that of nystatin.

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Hybrid compounds based on 4,6-dichloro-5-nitrobenzofuroxan, 7-chloro-4,6-dinitrobenzofuroxan, 5,7-dichloro-4,6-dinitrobenzofuroxan, and polyene antibiotics (amphotericin B and nystatin) have been prepared for the first time. They have exhibited biological activity comparable to that of starting antibiotics. Activity of the compound derived from 5,7-dichloro-4,6-dinitrobenzofuroxan and nystatin towards Trichophyton mentagrophytes is 4 times higher than that of nystatin.

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Available abstract

Hybrid compounds based on 4,6-dichloro-5-nitrobenzofuroxan, 7-chloro-4,6-dinitrobenzofuroxan, 5,7-dichloro-4,6-dinitrobenzofuroxan, and polyene antibiotics (amphotericin B and nystatin) have been prepared for the first time. They have exhibited biological activity comparable to that of starting antibiotics. Activity of the compound derived from 5,7-dichloro-4,6-dinitrobenzofuroxan and nystatin towards Trichophyton mentagrophytes is 4 times higher than that of nystatin.

Key concepts: Polyene, Nystatin, Chemistry, Antibiotics, Amphotericin B, Trichophyton, Microbiology, Natamycin

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